Precision medicine refers to the use of prevention and treatment strategies that are tailored to the unique features of each individual and their disease. In the context of cancer this might involve the identification of specific variants shown to predict response to a targeted therapy. The biomedical literature describing associations between genetic variants and clinically relevant outcomes is large and growing rapidly. Currently variant interpretations exist largely in private or encumbered databases resulting in extensive repetition of effort. Effective precision medicine requires this information to be centralized, debated, and interpreted for application in a clinical setting. CIViC is an open access, open source, community-driven web resource for Clinical Interpretation of Variants in Cancer, available online at civicdb.org. Our goal is to enable precision medicine by providing an educational forum for dissemination of knowledge and active discussion of the clinical significance of cancer genome alterations. For more details and to cite CIViC please refer to the CIViC publication in Nature Genetics.