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Alveolar Soft Part SarcomaClear Cell SarcomaDesmoplastic Small Round Cell TumorEndodermal Sinus TumorHepatoblastomaMelanomaNeuroblastomaOsteosarcomaRhabdomyosarcomaSarcoma...
267
401
Malignancy remains the leading cause of disease-related death in children. DNA sequencing studies have shown a paucity of actionable genomic alterations and a low mutation burden across pediatric cancers at diagnosis. We perform a comprehensive genomic and epigenomic analysis of pediatric tumor and normal tissues using next-generation sequencing to identify molecular fingerprints and targets for diagnosis, prognosis, and development of novel therapeutic methods. This study also represents one of ...
Breast Invasive Cancer, NOSBreast Invasive Carcinoma, NOSBreast Invasive Ductal CarcinomaBreast Invasive Lobular CarcinomaBreast Mixed Ductal and Lobular Carcinoma
76
Targeted sequencing of 428 breast cancer patients in the GENIE AKT1 Analysis cohort. The data presented here includes only those patients under the age of 40 years old.
Osteosarcoma
5
7
Lung metastasis is responsible for nearly all deaths caused by osteosarcoma, the most common pediatric bone tumor. How malignant bone cells coerce the lung microenvironment to support metastatic growth is unclear. This study delineates how osteosarcoma cells educate the lung microenvironment during metastatic progression.
Acute Leukemias of Ambiguous LineageAcute Lymphoblastic Leukemia, NOS
1,701
In the expansion effort (Phase 2), TARGET investigators analyzed tumors from pediatric patients, most who experienced an early bone marrow relapse (within 4 years of initial diagnosis), to identify new therapeutic approaches and/or biomarkers that correlate with poor clinical outcome to treat childhood pre-cursor B-cell ALL. The tissues used in this study were collected from patients enrolled in Children's Oncology Group (COG) biology studies and clinical trials. For Phase 3, leukemia can arise ...
Acute Lymphoblastic Leukemia, NOS
233
The TARGET ALL Pilot project has produced comprehensive genomic profiles of nearly 200 high-risk, clinically annotated, B-cell ALL patient cases from Children's Oncology Group (COG) for molecular alterations.
Project
Acute Myeloid Leukemia, NOS
2,146
The TARGET Acute Myeloid Leukemia projects elucidate comprehensive molecular characterization to determine the genetic changes that drive the initiation and progression of high-risk or hard-to-treat childhood cancers. Acute myeloid leukemia (AML) is a cancer that originates in the bone marrow from immature white blood cells known as myeloblasts. About 25% of all children with leukemia have AML.
Project
Acute Megakaryoblastic LeukaemiaAcute Monoblastic And Monocytic LeukaemiaAcute Myeloid Leukaemia, NOSAcute Myelomonocytic LeukaemiaAcute Promyelocytic Leukaemia with t(15;17)(q22;q12); PML-RARAAcute Undifferentiated LeukaemiaAML with inv(16)(p13.1q22) or t(16;16)(p13.1;q22); CBFB-MYH11AML with inv(3)(q21q26.2) or t(3;3)(q21;q26.2); RPN1-EVI1AML with MaturationAML with Minimal Differentiation...
129
Whole-exome and transcriptomic sequencing of 942 acute myeloid leukemia samples (with 500 matched normals) from the Beat AML program. The cases here are only those under the age of 40 years old.
Program
At Risk of Breast CancerBasal Cell Carcinoma of Auricle of EarBasal Cell Carcinoma of BackBasal Cell Carcinoma of Chest WallBasal Cell Carcinoma of ChinBasal Cell Carcinoma of EarBasal Cell Carcinoma of ForeheadBasal Cell Carcinoma of NeckBasal Cell Carcinoma of NoseBasal Cell Carcinoma of Scalp...
4,961
The All of Us Research Hub matches a broad research community with a diverse set of research participants. Its goal is to advance precision medicine research and fuel new insights into human health. The Research Hub houses one of the largest, most diverse, and most broadly accessible datasets ever assembled. It also provides an interactive Data Browser where anyone can learn about the type and quantity of data that All of Us collects. Users can explore aggregate data including genomic variants, ...
Project
Acute Lymphoblastic LeukemiaAcute Myeloid LeukemiaAcute Undifferentiated LeukemiaB-Cell Acute Lymphoid LeukemiaLeukemiaT-Cell Acute Lymphoid Leukemia
93
Targeted SequencingWhole Exome SequencingWhole Genome Sequencing
93
Comprehensive profiling of infant MLL-rearranged acute lymphoblastic leukemia (MLL-R ALL).
Project
Acute Lymphoid Leukemia
73
Whole Exome SequencingWhole Genome Sequencing
73
Whole-genome and/or whole-exome sequencing of ERG-altered B-ALL tumor/normal pairs.
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