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Five new datasets in May 2025
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May 08, 2025

The May 2025 Childhood Cancer Data Initiative Data Catalog (CCDC) release features updated counts and resource details for many resources and four new datasets: CBTRUS Fact Sheet 2024, Childhood Cancer Data Initiative (CCDI): Pediatric In Vivo Testing Program - Neuroblastoma, GENIE Cohort v17.0-public, and IDC’s Pediatric-CT-SEG. A fifth new dataset has been added along with a new resource: the Childhood Cancer Catalog of Extrachromosomal DNA. The footer has been updated for consistent styling and user experience across NCI CCDI applications and help text was added to the About page to provide information for citing the Data Catalog. Detailed updates are below.

Data Updates

New Resources

1 new resource has been added.

  • Childhood Cancer Catalog of Circular Extrachromosomal DNA (ecDNA)

    • New Dataset – Childhood Cancer Catalog of Circular Extrachromosomal DNA (ecDNA)

Existing Participating Resources and Datasets

16 existing resources have been updated with additional data and information or with datasets removed.

  • Central Brain Tumor Registry of the United States (CBTRUS)

    • New Dataset – CBTRUS Fact Sheet 2024

  • Childhood Cancer Data Initiative (CCDI)

    • New Dataset – Childhood Cancer Data Initiative (CCDI): Pediatric In Vivo Testing Program - Neuroblastoma

    • Updated dataset counts for:

      • UCSF Database for the Advancement of JMML - Integration of Metadata with "Omic" Data

      • Childhood Cancer Data Initiative (CCDI): Molecular Characterization Initiative

      • Childhood Cancer Data Initiative (CCDI): Molecular Characterization across Pediatric Brain Tumors and Other Solid and Hematologic Malignancies for Research, Diagnostic, and Precision Medicine

  • Clinical Interpretations of Variants in Cancer (CIViC)

    • Updated case disease list

  • Fibrolamellar Registry

    • Added counts

  • Genomics Evidence Neoplasia Information Exchange (GENIE)

    • New Dataset – GENIE Cohort v17.0-public

    • Removed dataset – GENIE Cohort v16.1-public

  • NCI Imaging Data Commons (IDC)

    • New Dataset – Pediatric-CT-SEG

  • Oncogenomics

    • Removed dataset – Melanoma NCT00590844_CCR

  • OncoKB

    • Updated case disease list

  • PDX Development and Trial Centers Research Network (PDXNet)

    • Updated counts and added data elements for datasets:

      • PDXNet Portal Model

      • PDXNet Portal PDMR Data

    • Updated resource description

    • Updated resource and contact POCs

    • Updated resource URL

  • Pediatric Cancer Data Commons

    • Updated counts for datasets:

      • International Soft Tissue Sarcoma Consortium (INSTRuCT)

      • International Neuroblastoma Risk Group (INRG)

      • Hodgkin Lymphoma Data Collaboration (NODAL)

      • Malignant Germ Cell International Consortium (MaGIC)

      • International Acute Myeloid Leukemia Consortium (INTERACT)

  • Single-cell Pediatric Cancer Atlas

    • Updated resource description and references

    • Updated dataset SCPCP000024 to include cell lines

  • Therapeutically Applicable Research To Generate Effective Treatments

    • Added available files for OS and MDLS-NBL datasets

    • Updated dataset counts for:

      • Acute Lymphoblastic Leukemia (ALL) Pilot Phase 1

      • Acute Myeloid Leukemia (AML)

      • Neuroblastoma (NBL)

      • Osteosarcoma (OS)

    • Combined ALL Phase 2 and ALL Phase 3 into Acute Lymphoblastic Leukemia (ALL) Expansion Phase 2 and Acute Leukemias of Ambiguous Lineage (ALAL) Phase 3

    • Combined MDLS-NBL and MDLS-PPTP into Cancer Model Systems (MDLS): NBL and Pediatric Preclinical Testing Program (PPTP)

  • Texas KidsCanSeq

    • Updated resource URL

  • The Cancer Imaging Archive

    • Updated dataset Pediatric-CT-SEG

  • Victorian Paediatric Cancer Consortium

    • Updated counts

  • Xena Browser

    • Updated case disease list

General Site Updates

  • The footer was updated to organize contact link and provide consistent styling across CCDI applications.
  • The About page was updated to include description of how to cite the application.
  • The User Guide was updated with new content to reflect up-to-date application and resource descriptions.

Additional Support and Inquiries

Users requiring any additional support or with any questions about the CCDC can contact the Childhood Cancer Data Initiative at NCIChildhoodCancerDataInitiative@mail.nih.gov . Please include a name and a reference to the CCDC with the submitted inquiry.