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In vitro prednisolone resistance signature in MLL-rearranged infant ALL
GEO
Data Resource:  GEO
Point of Contact:  
Jill Spijkers-Hagelstein,  
Project

About This Dataset
Acute Lymphoblastic Leukemia (ALL) in infants (<1 year of age) is characterized by a high incidence of MLL translocations which is associated with a poor prognosis. Contributing to this poor prognosis is cellular drug resistance, especially to glucocorticoids like prednisolone. Although in vitro prednisolone resistance mechanisms have been proposed in pediatric ALL, it has never been studied in MLL-rearranged infant ALL, which are highly resistant to glucocorticoids in vitro and in vivo.
Core Data Elements
Case Sex
Not Reported ()
Case Age At Diagnosis
0 to 4 years ()
Case Race
Not Reported ()
Case Ethnicity
Not Reported ()
Case Disease Diagnosis
Acute Lymphoblastic Leukemia ()
Case Tumor Site
Peripheral Blood ()
Additional Data Elements
GEO STUDY IDENTIFIER
Published In
https://doi.org/10.1038/leu.2011.388