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Childhood Cancer Data Initiative (CCDI): Molecular Characterization across Pediatric Brain Tumors and Other Solid and Hematologic Malignancies for Research, Diagnostic, and Precision Medicine
CCDI
Data Resource:  CCDI
Point of Contact:  
Allison Heath, PhD,  
Project

About This Dataset
This study contains tumor and germline WGS, RNA-Seq, Clinical Panel Sequencing, and other omics and molecular data for patients with pediatric brain tumors and other solid and hematologic malignancies. This data has been collected from multiple organizations including the multi-institute Children's Brain Tumor Network (CBTN), the Pacific Pediatric Neuro-Oncology Consortium (PNOC), and the Children's Hospital of Philadelphia Division for Genomic Diagnostics (CHOP DGD). In 2019, the CBTN launched the Pediatric Brain Tumor Atlas, which now comprises the largest collection of childhood brain tumor data in the world. This resource is helping accelerate not only brain tumor research, but is also empowering discovery for other rare childhood conditions. This sequencing cohort defines the largest, clinically annotated pediatric brain tumor cohort study to date and seeks to define the intersection of germline and somatic underpinnings of pediatric brain tumors across a shared developmental context of cancer and structural birth defects.
Core Data Elements
Number of Cases
3,941
Case Sex
Female (1,919); Male (2,022)
Case Age At Diagnosis
0 to 4 years (732); 5 to 9 years (714); 10 to 14 years (741); 15 to 19 years (478); 20 to 24 years (125); 25 to 29 years (38); 30 to 34 years (20); 35 to 39 years (9); Greater than 39 years (38); Pediatric and Young Adult (<40 years) (1,046)
Case Race
American Indian or Alaska Native (9); Asian (103); Black or African American (214); More Than One Race (330); Native Hawaiian or Other Pacific Islander (7); White (1,750); Not Reported (1,495); Unknown (33)
Case Ethnicity
Hispanic or Latino (326); Not Hispanic or Latino (2,103); Not Reported (1,479); Unknown (33)
Case Disease Diagnosis
Adenoma (8); Astrocytoma (182); Astrocytoma, benign (347); Atypical Teratoid/Rhabdoid Tumor (41); Atypical teratoid/rhabdoid tumor (36); Cavernous hemangioma (7); Central neurocytoma (2); Central Neurocytoma (1); Chordoma (5); Chordoma (including poorly differentiated chordoma) (6); Choroid Plexus Carcinoma (7); Choroid plexus carcinoma (6); Choroid plexus papilloma (13); Choroid Plexus Papilloma (11); Choroid Plexus tumors (26); CNS embryonal tumor (16); CNS Germ Cell Tumors (22); CNS Germinoma (14); CNS Non-Germinomatous Germ Cell Tumor (1); CNS Sarcoma (28); Craniopharyngioma (116); Diffuse midline glioma, H3 K27M-mutant (50); Dysembryoplastic neuroepithelial tumor (25); Dysembryoplastic Neuroepithelial Tumor (12); Embryonal tumor with multilayered rosettes (5); Embryonal tumor with multilayered rosettes with C19MC alteration (4); Ependymoma (228); Ewing Sarcoma (10); Ganglioglioma (75); Ganglioglioma, benign (14); Ganglioneuroblastoma (3); Germ cell tumor, nonseminomatous (1); Germinoma (13); Glioneuronal and neuronal tumors (88); Hemangioblastoma (6); High-Grade Glioma (201); Langerhans Cell Histiocytosis (4); Langerhans cell histiocytosis, disseminated (1); Low-Grade Glioma (370); Low-grade glioma or NEC (1); Malignant lymphoma, non-Hodgkin (2); Malignant peripheral nerve sheath tumor (6); Medulloblastoma (285); Medulloblastoma or NEC (1); Melanotic schwannoma (30); Meningioma (36); Neoplasm, metastatic (5); Neuroblastoma (6); Oligodendroglioma (44); Other (377); Other CNS Embryonal tumors (23); Pineoblastoma (11); Pituitary adenoma/PitNET (9); Plexiform neurofibroma (25); Rhabdomyosarcoma (2); Sarcoma (12); Subependymal giant cell astrocytoma (5); Subependymal Giant Cell Astrocytoma (3); Teratoma, malignant (11); Not Reported (1,042)
Case Tumor Site
Bones of Skull and Face and Associated Joints (73); Brain Stem (185); Cerebellum, NOS (763); Cerebral Meninges (49); Cerebrum (262); Frontal Lobe (299); Occipital Lobe (17); Optic Nerve (64); Parietal Lobe (189); Pineal Gland (34); Pituitary Gland (235); Spinal Cord (254); Spinal Cord, Cranial Nerves, and Other Parts of Central Nervous System (11); Temporal Lobe (283); Ventricle, NOS (276); Not Reported (821); Unknown (126)
Number of Samples
8,951
Sample Assay Method
miRNA Sequencing (22); Other (1,616); RNA Sequencing (2,300); Targeted Capture (2); Whole Exome Sequencing (166); Whole Genome Sequencing (6,460)
Sample Is Normal
No (5,042); Yes (3,838); Not Reported (71)
Additional Data Elements
DBGAP STUDY IDENTIFIER
Grant Information
3P30CA082103-21S9
Cancer Center Support Grant
X01CA267587
Charts
Male (2,022); Female (1,919)
2,022Male