The Norwegian Childhood Cancer Biobank (NCCB) is a prospective biobank including infants, children, and adolescents from 0 to 18 years of age diagnosed with cancer in Norway. The overall aim of the NCCB is to stimulate and facilitate basic and translational research within childhood cancer through a national pipeline for biobanking tumor, microbiotic, and germline tissue at all regional childhood cancer departments and from all children with newly diagnosed cancer in Norway, providing the basis for advanced childhood cancer research on a national and international basis.