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Transient treatment with epigenetic modifiers yields stable neuroblastoma stem cells resembling aggressive large-cell neuroblastom...
Transient treatment with epigenetic modifiers yields stable neuroblastoma stem cells resembling aggressive large-cell neuroblastomas
Data Resource:
GEO
Point of Contact:
Eric Rappaport
,
rappaport@email.chop.edu
Project
About This Dataset
Cancer stem cells are plastic in nature, a characteristic that hampers cancer therapeutics. Neuroblastoma (NB) is a pediatric tumor of neural crest origin, and half of the cases are highly aggressive. By treating NB cell lines (SKNAS, SKNBE(2)C, CHP134, SY5Y) with epigenetic modifiers for a short time followed by sphere-forming culture conditions, we have established stem cell-like NB cells that are phenotypically stable for over a year.
Core Data Elements
Case Sex
Not Reported ()
Case Age At Diagnosis
Pediatric and Young Adult (<40 years) ()
Case Race
Not Reported ()
Case Ethnicity
Not Reported ()
Case Disease Diagnosis
Neuroblastoma ()
Case Tumor Site
Brain ()
Additional Data Elements
GEO STUDY IDENTIFIER
GSE44537
GSE44537
Published In
https://doi.org/10.1073/pnas.1118262110
https://doi.org/10.1073/pnas.1118262110