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NSD2 E1099K Drives Relapse in Pediatric Acute Lymphoblastic Leukemia by Disrupting 3D Chromatin Organization
dbGaP
Data Resource:  dbGaP
Point of Contact:  
William L. Carroll,  
Project

About This Dataset
NSD2 p.E1099K (EK) is a mutation shown to be enriched in patients that relapse with pediatric Acute Lymphoblastic Leukemia (ALL). This work aims to uncover 3D chromatin architecture-related mechanisms responsible for drug resistance or therapy failure in these patients. We investigated this by performing Hi-C, ATAC-Seq, and RNA-Seq on three B-ALL cell lines heterozygous for EK either expressing a NSD2 targeting small RNA (sRNA) or a non-targeting small hairpin RNAs (shRNA). We also performed RNA-Seq on three matched diagnosis/relapse B-ALL samples with the relapse enriched EK mutation.
Core Data Elements
Number of Cases
6
Case Sex
Unknown (6)
Case Age At Diagnosis
Pediatric and Young Adult (<40 years) (6)
Case Race
Not Reported (6)
Case Ethnicity
Not Reported (6)
Case Disease Diagnosis
Acute Lymphoblastic Leukemia (6)
Case Tumor Site
Bone Marrow (6)
Number of Samples
6
Sample Analyte Type
DNA/RNA (6)
Additional Data Elements
CLINICAL TRIAL IDENTIFIER
DBGAP STUDY IDENTIFIER
GEO STUDY IDENTIFIER
SRA STUDY IDENTIFIER
Grant Information
5R01CA140729-10
Drug resistant pathways in relapsed acute lymphoblastic leukemia (ALL)
Published In
https://doi.org/10.1158/1541-7786.mcr-20-0092;https://doi.org/10.1101/2022.02.24.481835
Charts
Unknown (6)
6Unknown