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Exploring the Microbiome-Gut-Brain Axis with Respect to Psychoneurological Symptoms for Children with Solid Tumors
dbGaP
Data Resource:  dbGaP
Point of Contact:  
Jinbing Bai, PhD, RN,  
Project

About This Dataset
The human body hosts tens of trillions of microbes, a number 10 times greater than the number of human body cells. The collection of these human-associated microbes and their genomes is called the "human microbiome". More than 90% of these microbes live in the gastrointestinal (GI) tract, representing 500 species on average. With the development of high-throughput sequencing technology and bioinformatics tools (e.g., 16S ribosomal RNA or 16S rRNA sequencing and shotgun metagenomics analysis), recent progress has been made to elaborate the critical role that the gut microbiome plays in human health and disease. A significant disruption (dysbiosis) of the composition and function of the gut microbiome is associated with carcinogenesis, chemotherapeutic metabolism, and treatment-related symptom toxicities. The current state of science on the gut microbiome in cancer has only recently started in animal models and adults, and has not been well investigated in children diagnosed and treated for cancer, nor with respect to associations with cancer treatment-related toxicities. This proposed study will explore the hypothesis that dysbiosis of the gut microbiome is associated with cancer treatment-related GI and psychoneurological symptoms. We will collect both stool samples (for the gut microbiome) and patient-reported outcomes across chemotherapy.
Core Data Elements
Number of Cases
44
Case Sex
Female (22); Male (22)
Case Age At Diagnosis
5 to 9 years (14); 10 to 14 years (15); 15 to 19 years (13); 20 to 24 years (2)
Case Race
Not Reported (44)
Case Ethnicity
Hispanic or Latino (6); Not Hispanic or Latino (37); Unknown (1)
Case Disease Diagnosis
Ewing's Sarcoma (5); Langerhans Cell Histiocytoses (1); Nasopharyngeal Carcinoma (2); Neuroblastoma (1); Osteosarcoma (11); Primary Mediastinal Seminoma (1); Rhabdomyosarcoma (1); Sarcoma of Bone (1); Sarcoma of Soft Tissue (2); Synovial Sarcoma (2); Not Reported (17)
Number of Samples
57
Sample Analyte Type
16S rRNA (57)
Sample Anatomic Site
Gut (57)
Additional Data Elements
DBGAP STUDY IDENTIFIER
Grant Information
K99NR017897
Exploring the Microbiome-Gut-Brain Axis in Psychoneurological Symptoms for Children with Solid Tumors
Charts
Female (22); Male (22)
22Female