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Genetic Underpinnings of Ethnic Disparities in Bone Toxicities Between Hispanic and Non-Hispanic Children Treated for Acute Lymphoblastic Leukemia
dbGaP
Data Resource:  dbGaP
Point of Contact:  
Song Yao,  
Project

About This Dataset
Acute lymphoblastic leukemia (ALL) is the most common malignancy among children and young adolescents. More than 90% of children are cured with a combination of multiple chemotherapeutic drugs. Some may suffer from debilitating toxicities due to the cytotoxic drugs, necessitating pharmacogenetic research to search for genetic markers predictive of treatment toxicities, so that treatment can be better tailored based on patients' genetic makeup. Bone toxicities, including osteonecrosis and fractures, most often due to glucocorticoids, are the most common complications in ALL, which have long-lasting detrimental impact on the still developing skeletons in children. In DFCI ALL Consortium Protocol 05-001, a multi-center clinical trial for childhood ALL conducted in Canada and the US, we found that Hispanic children had less drug toxicities to their bones than non-Hispanic children. Although reasons for the observed ethnic differences are largely unknown, patients' inherited genetic background may be at play. This study seeks to perform a novel pharmacogenomic study based on a multi-site clinical trial DFCI-ALL Consortium Protocol 05-001 to identify genetic underpinnings of ethnic disparities in bone toxicities.
Core Data Elements
Number of Cases
415
Case Sex
Female (185); Male (230)
Case Age At Diagnosis
0 to 4 years (158); 5 to 9 years (132); 10 to 14 years (76); 15 to 19 years (49)
Case Race
Asian (14); Black or African American (20); White (260); Not Reported (121)
Case Ethnicity
Hispanic or Latino (75); Not Hispanic or Latino (340)
Case Disease Diagnosis
Acute Lymphoblastic Leukemia (415)
Case Tumor Site
Bone Marrow or Peripheral Blood (415)
Additional Data Elements
CLINICAL TRIAL IDENTIFIER
DBGAP STUDY IDENTIFIER
Grant Information
5P01CA068484
Therapeutic Index of Acute Lymphoblastic Leukemia
P30CA016056
Roswell Park Cancer Center Support Grant
R03CA223730
Genetic underpinnings of ethnic disparities in bone toxicities between Hispanic and non-Hispanic children treated for acute lymphoblastic leukemia
R25CA094061
Training Program in Cancer-Related Population Sciences
Published In
https://doi.org/10.1016/s1470-2045(15)00363-0;https://doi.org/10.1002/pbc.26871;https://doi.org/10.1182/bloodadvances.2020003060
Charts
Male (230); Female (185)
230Male