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Genomic Landscape of Pediatric Germ Cell Tumors
dbGaP
Data Resource:  dbGaP
Point of Contact:  
James Amatruda, PhD,  
Project

About This Dataset
Germ cell tumors (GCTs) are cancers of the testis, ovary and extragonadal sites that occur in infants, children, adolescents, and adults. Post-pubertal (type II) malignant GCTs may present as a seminoma, non-seminoma or with mixed histologies. In contrast, pre-pubertal (type I) GCTs are limited to (benign) teratomas and (malignant) yolk sac tumors (YST). Epidemiologic and molecular data have shown that pre- and post-pubertal GCTs arise by distinct mechanisms. Dedicated studies of the genomic landscape of type I and II GCTs in children and adolescents are lacking. Here we present an integrated genomic analysis of extracranial GCTs across the age spectrum from 0-24 years.
Core Data Elements
Number of Cases
94
Case Sex
Female (35); Male (56); Not Reported (3)
Case Age At Diagnosis
0 to 4 years (44); 5 to 9 years (4); 10 to 14 years (15); 15 to 19 years (28); 20 to 24 years (2); Pediatric and Young Adult (<40 years) (1)
Case Race
Not Reported (94)
Case Ethnicity
Not Reported (94)
Case Disease Diagnosis
Blue Cell Tumor Arising in Teratoma (2); Embryonal Carcinoma (4); Mixed Malignant Germ Cell Tumor (20); Seminoma (12); Teratoma (4); Yolk Sac Tumor (52)
Number of Samples
32
Sample Analyte Type
RNA (32)
Additional Data Elements
DBGAP STUDY IDENTIFIER
Grant Information
R01CA135731
Generation and Rapid Mapping of Low-Penetrance Disease Alleles in Zebrafish
R01CA151284
Molecular Epidemiology of Pediatric Germ Cell Tumors
U24CA114766
Support for Human Specimen Banking in NCI-Sponsored Clinical Trials-(CGB)
Published In
https://doi.org/10.1016/j.devcel.2019.11.007;https://doi.org/10.1111/andr.12644
Charts
Male (56); Female (35); Not Reported (3)
56Male