US Flag logoAn official website of the United States government
A Comprehensive Genomic Study of Pediatric Malignancy
dbGaP
Data Resource:  dbGaP
Point of Contact:  
Javed Khan,  
Project

About This Dataset
Malignancy remains the leading cause of disease-related death in children. DNA sequencing studies have shown a paucity of actionable genomic alterations and a low mutation burden across pediatric cancers at diagnosis. We perform a comprehensive genomic and epigenomic analysis of pediatric tumor and normal tissues using next-generation sequencing to identify molecular fingerprints and targets for diagnosis, prognosis, and development of novel therapeutic methods. This study also represents one of the largest of its type to date and provides a rich genomic dataset for the pediatric cancer research community.
Core Data Elements
Number of Cases
267
Case Sex
Not Reported (267)
Case Age At Diagnosis
Pediatric and Young Adult (<40 years) (267)
Case Race
Not Reported (267)
Case Ethnicity
Not Reported (267)
Case Disease Diagnosis
Alveolar Soft Part Sarcoma (); Clear Cell Sarcoma (); Desmoplastic Small Round Cell Tumor (); Endodermal Sinus Tumor (); Hepatoblastoma (); Melanoma (); Neuroblastoma (); Osteosarcoma (); Rhabdomyosarcoma (); Sarcoma (); Synovial Sarcoma (); Teratoma (); Wilms Tumor ()
Number of Samples
401
Sample Anatomic Site
Adrenal Gland (9); Ascending Colon (2); Bladder (9); Cerebellum (10); Cerebrum (9); Colon (3); Descending Colon (4); Heart (6); Ileum (9); Kidney (9); Liver (9); Lung (9); Ovary (4); Pancrease (5); Prostate (10); Skeletal Muscle (10); Spleen (4); Stomach (6); Testis (6); Ureter (6); Uterus (6); Not Reported (256)
Sample Is Normal
Yes (147); No (254)
Additional Data Elements
DBGAP STUDY IDENTIFIER
GRANT
Intramural Research Program of the Center for Cancer Research, NCI
Charts
Not Reported (267)
267Not Reported