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Elucidating Transcription Regulation by Epigenetics in Neuroblastoma
dbGaP
Data Resource:  dbGaP
Point of Contact:  
Mark Applebaum MD,  
Project

About This Dataset
Whole-genome profiles of the epigenetic modification 5-hydroxymethylcytosine (5-hmC) are robust diagnostic biomarkers in adult patients with cancer. We investigated if 5-hmC profiles would serve as novel prognostic markers in neuroblastoma, a clinically heterogeneous pediatric cancer. Because this DNA modification facilitates active gene expression, we hypothesized that 5-hmC profiles would identify transcriptomic networks driving the clinical behavior of neuroblastoma.
Core Data Elements
Number of Cases
189
Case Sex
Female (89); Male (100)
Case Age At Diagnosis
0 to 4 years (126); 5 to 9 years (39); 10 to 14 years (13); 15 to 19 years (9); 25 to 29 years (2)
Case Race
Asian (1); Black or African American (27); White (144); Unknown (17)
Case Ethnicity
Hispanic or Latino (35); Not Hispanic or Latino (140); Unknown (14)
Case Disease Diagnosis
Neuroblastoma (189)
Case Tumor Site
Not Reported (189)
Number of Samples
287
Sample Is Normal
Yes (130); No (157)
Additional Data Elements
DBGAP STUDY IDENTIFIER
Grant Information
K08CA226237
Elucidating transcription regulation by epigenetics in neuroblastoma
K12CA139160
Developing an Oncology Workforce for the 21st Century
UL1TR002389
ITM 2.0: Advancing Translational Science in Metropolitan Chicago
Published In
https://doi.org/10.1200/po.18.00402
Charts
Male (100); Female (89)
100Male