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Mechanisms of Chemotherapy Resistance in T-ALL
dbGaP
Data Resource:  dbGaP
Point of Contact:  
Alejandro Gutierrez, MD,  
Project

About This Dataset
The goals of this study are to unravel the molecular mechanisms underlying leukemic transformation and chemotherapy resistance in T-cell acute lymphoblastic leukemia (T-ALL). Towards this end, a cohort of T-ALL lymphoblast specimens was collected at the time of initial T-ALL diagnosis (prior to the start of therapy) from children enrolled on contemporary clinical trials, Children's Oncology Group study AALL0434 and Dana-Farber Cancer Institute 05-001. Samples were analyzed using targeted exon sequencing and RNA sequencing analysis. Results of these analyses form the basis of studies that have been submitted for publication, and will be linked to this entry once published.
Core Data Elements
Number of Cases
109
Case Sex
Female (39); Male (70)
Case Age At Diagnosis
0 to 4 years (24); 5 to 9 years (35); 10 to 14 years (26); 15 to 19 years (22); 20 to 24 years (1); Greater than 39 years (1)
Case Race
Not Reported (109)
Case Ethnicity
Not Reported (109)
Case Disease Diagnosis
T-cell Acute Lymphoblastic Leukemia (109)
Number of Samples
109
Sample Assay Method
RNA Sequencing (24); Whole Exome Sequencing (85)
Sample Anatomic Site
Bone Marrow (69); Thymus (40)
Additional Data Elements
DBGAP STUDY IDENTIFIER
Grant Information
R01CA193651
Defining and targeting asparaginase resistance mechanisms in high-risk acute leukemias
R21CA167124
Discovery and Targeting of Apoptosis Resistance Mechanisms in High-Risk T-ALL
Charts
Male (70); Female (39)
70Male