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Identification of 22 Novel Loci Associated with Susceptibility to Testicular Germ Cell Tumors
dbGaP
Data Resource:  dbGaP
Point of Contact:  
Katherine Nathanson, MD,  
Project

About This Dataset
Testicular germ cell tumors (TGCT) are the most common cancers in young men of European ancestry aged 20 to 39 years. The Testicular Cancer Consortium (TECAC) has brought together the largest genome-wise association study (GWAS) study of TGCT to date. We conducted a GWAS of 5,602 cases and 5,006 controls aggregated from 12 locations in the US and Europe. Logistic regression models adjusted for study center and genomic ancestry. Genotypes were imputed against the Human Haplotype Reference Consortium. Meta-analysis was performed to combine GWAS results with summary statistics from five previously published TGCT studies, UK Biobank, deCODE Genetics, and an independent set of cases and controls, for a total of 10,156 cases and 179,683 controls. 22 novel and 45 previously reported loci associated with TGCT surpassed genome-wide significance.
Core Data Elements
Number of Cases
10,608
Case Sex
Female (548); Male (10,060)
Case Age At Diagnosis
Pediatric and Young Adult (<40 years) (10,608)
Case Race
White (8,005); Not Reported (2,603)
Case Ethnicity
Hispanic or Latino (128); Not Hispanic or Latino (7,080); Not Reported (3,400)
Case Disease Diagnosis
Testicular Germ Cell Tumors (10,608)
Additional Data Elements
DBGAP STUDY IDENTIFIER
Grant Information
R01CA114478
Inherited genetic variation and predisposition to testicular germ cell tumor
U01CA164947
Post genome wide association studies in testicular germ cell tumors
Published In
https://doi.org/10.1038/ng.393;https://doi.org/10.1038/ng.3896;https://doi.org/10.1038/ng.3879;https://doi.org/10.1093/hmg/ddr207
Charts
Male (10,060); Female (548)
10,060Male