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Pathogenesis and Immunity in Endemic Burkitt Lymphoma
dbGaP
Data Resource:  dbGaP
Point of Contact:  
Ann M. Moormann,  
Project

About This Dataset
This genomic landscape of Burkitt lymphoma represents a multimodal sequencing of tumors and control tissues and individuals to better understand the etiology, and molecular pathogenesis of Burkitt lymphoma including the roles of the associated Plasmodium falciparum malaria and EBV infections. Comprehensive sequencing set includes genomic, transcriptomic, and epigenomic datasets in concert with variable clinical phenotypes and outcome information such as anatomical presentation site, in-hospital survival rates, and EBV genome type. This deposit includes additional small RNA-seq data from endemic BL (eBL) tumors and RNA-sequencing data from sorted NK cell subsets from the peripheral blood of eBL patients. The additional small RNA-seq data are from tumor specimens from 17 eBL cases, of the previously deposited polyA RNA-seq data from 28 eBL cases (phs1282.V1). The additional RNAseq data from Fluorescence-activated cell sorting (FACS) of NK cell subsets, isolated from the peripheral blood of 7 eBL cases.
Core Data Elements
Number of Cases
39
Case Sex
Female (8); Male (29); Not Reported (2)
Case Age At Diagnosis
0 to 4 years (3); 5 to 9 years (22); 10 to 14 years (12); Pediatric and Young Adult (<40 years) (2)
Case Race
Black or African American (39)
Case Ethnicity
Not Hispanic or Latino (39)
Case Disease Diagnosis
Burkitt Lymphoma (39)
Case Tumor Site
Abdomen (17); Blood (7); Jaw (12); Jaw and Blood (1); Not Reported (2)
Additional Data Elements
DBGAP STUDY IDENTIFIER
Grant Information
R01CA134051
T Cell Immunity in Endemic Burkitt Lymphoma
R01CA189806
Impact of malaria on shaping immunity to EBV in the etiology of Burkitt lymphoma
Published In
https://doi.org/10.1158/1541-7786.mcr-16-0305;https://doi.org/10.1002/ijc.30170
Charts
Male (29); Female (8); Not Reported (2)
29Male