CCDC - Childhood Cancer Data Catalog

Transcriptome Sequencing of Pediatric Neuroblastoma

dbGaP

Data Resource: dbGaP

Point of Contact:

Javed Khan,

khanjav@mail.nih.gov

Project

About This Dataset

Neuroblastoma is the most common extra-cranial solid tumor in children. It represents 8% to 10% of all childhood cancers. Stage 4 Neuroblastoma is characterized by its clinical heterogeneous outcome. The special category, stage 4S tumors (2-5% of all NB) are chemo-sensitive, and the patients show spontaneous regression. On the other hand, MYCN amplification (25-30% of all NB) is associated with poor outcome of neuroblastoma, thus we further categorize stage 4 neuroblastoma into MYCN non-amplified and MYCN amplified group. Here we use transcriptome sequencing to characterize the transcriptome in 29 stage 4 Neuroblastoma samples.

Core Data Elements

Number of Cases

29

Case Sex

Female (11); Male (18)

Case Age At Diagnosis

0 to 4 years (22); 5 to 9 years (6); 10 to 14 years (1)

Case Race

Not Reported (29)

Case Ethnicity

Not Reported (29)

Case Disease Diagnosis

Pediatric Neuroblastoma (29)

Case Tumor Site

Brain (29)

Number of Samples

29

Sample Assay Method

RNA Sequencing (29)

Additional Data Elements

DBGAP STUDY IDENTIFIER

Charts

Male (18); Female (11)