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Genomic and Transcriptomic Landscape of Fibrolamellar Hepatocellular Carcinoma
dbGaP
Data Resource:  dbGaP
Point of Contact:  
Sanford Simon, PhD,  
Project

About This Dataset
Fibrolamellar hepatocellular carcinoma (FL-HCC) is a rare liver tumor primarily affecting adolescents and young adults. Little is known of the molecular pathogenesis. To characterize the disease we performed RNA sequencing and whole genome sequencing on FL-HCC tumors and adjacent normal tissue. The results demonstrate few consistent differences on the chromosomal level and many hundreds of alterations in the expression of RNA transcripts.
Core Data Elements
Number of Cases
9
Case Sex
Female (5); Male (4)
Case Age At Diagnosis
15 to 19 years (3); 20 to 24 years (3); 25 to 29 years (1); 30 to 34 years (1); 35 to 39 years (1)
Case Race
Not Reported (9)
Case Ethnicity
Not Reported (9)
Case Disease Diagnosis
Fibrolamellar Hepatocellular Carcinoma (9)
Case Tumor Site
Liver (9)
Number of Samples
29
Sample Assay Method
Whole Genome Sequencing (29)
Sample Is Normal
Yes (9); No (20)
Additional Data Elements
DBGAP STUDY IDENTIFIER
Grant Information
UL1TR000043
Transforming Translational Science and Education to Benefit Human Health
Published In
https://doi.org/10.1126/science.1249484;https://doi.org/10.1073/pnas.1424894112;https://doi.org/10.18632/oncotarget.2712
Charts
Female (5); Male (4)
5Female