US Flag logoAn official website of the United States government
University of Michigan Clinical Sequencing Exploratory Research
dbGaP
Data Resource:  dbGaP
Point of Contact:  
Arul Chinnaiyan,  
Project

About This Dataset
Cancer is caused by a diverse array of somatic and germline genomic aberrations. Advances in genomic sequencing technologies have improved the ability to detect these molecular aberrations with greater sensitivity. However, integrating them into clinical management in an individualized manner has proven challenging. In this single center case series of children and young adults with relapsed or refractory cancer, incorporation of data from integrative clinical sequencing into clinical management was feasible, revealed potentially actionable findings in 46% of patients, and was associated with change in treatment and family genetic counseling in a small proportion of patients. The lack of a control group limited our ability to judge whether better clinical outcomes were achieved compared to standard care.
Core Data Elements
Number of Cases
102
Case Sex
Female (50); Male (52)
Case Age At Diagnosis
Pediatric and Young Adult (<40 years) (102)
Case Race
Not Reported (102)
Case Ethnicity
Not Reported (102)
Case Disease Diagnosis
Brain Tumor (8); Leukemia (25); Liver Tumor (7); Lymphoma (4); Neuroblastoma (9); Other Hematological Malignancy (3); Other Solid Tumor (11); Ovarian Tumor (3); Renal Tumor (3); Sarcoma (29)
Case Tumor Site
Not Reported (102)
Additional Data Elements
DBGAP STUDY IDENTIFIER
CASE AGE AVERAGE
10.6
CASE AGE MAXIMUM
22
CASE AGE MINIMUM
0
Grant Information
UM1HG006508
Exploring Precision Cancer Medicine for Sarcoma and Rare Cancers
Published In
https://doi.org/10.1001/jama.2015.10080
Charts
Male (52); Female (50)
52Male