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Hyperdiploid Acute Lymphoblastic Leukemia RNA-Seq
dbGaP
Data Resource:  dbGaP
Point of Contact:  
Patrick Brown, MD, PhD,  
Project

About This Dataset
Few genetic drivers of children with hyperdiploid precursor B-cell acute lymphoblastic leukemia (ALL) have been identified to date. In an effort to detect novel genomic rearrangements that could be promoting leukemogenesis in this subset of patients, we sequenced ribosomal RNA-depleted transcriptomes isolated from 5 hyperdiploid acute lymphoblastic leukemia samples. In addition to looking for novel genomic rearrangements, we also sought to identify transcripts that could be created as a result of a novel posttranscriptional process. Surprisingly, we identified transcripts created as the result of exon circularization.
Core Data Elements
Number of Cases
5
Case Sex
Not Reported (5)
Case Age At Diagnosis
Pediatric and Young Adult (<40 years) (5)
Case Race
Not Reported (5)
Case Ethnicity
Not Reported (5)
Case Disease Diagnosis
Hyperdiploid Acute Lymphoblastic Leukemia (5)
Case Tumor Site
Bone Marrow (5)
Additional Data Elements
DBGAP STUDY IDENTIFIER
GEO STUDY IDENTIFIER
Published In
https://doi.org/10.1371/journal.pone.0030733
Charts
Not Reported (5)
5Not Reported