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Neuroblastoma Genome-Wide Association Study
dbGaP
Data Resource:  dbGaP
Point of Contact:  
John M. Maris,  
Project

About This Dataset
Neuroblastoma is a malignancy of the developing sympathetic nervous system that most commonly affects young children and is often lethal. The etiology of this embryonal cancer is not fully understood. We therefore initiated a genome-wide association study (GWAS) in 2007 focused on neuroblastoma patients identified through the Children's Oncology Group (COG; 238 member institutions). Control patients for this study are children cared for at the Children's Hospital of Philadelphia (CHOP) without a diagnosis or family history of cancer. The study was initially designed to genotype 5,000 neuroblastoma cases and 10,000 controls and is powered to detect common susceptibility variants in Caucasian and African American patients. Whole genome genotyping was performed on multiple versions of Illumina SNP arrays. This version of the study represents the complete set of cases genotyped.
Core Data Elements
Number of Cases
5,000
Case Sex
Not Reported (5,000)
Case Age At Diagnosis
Pediatric and Young Adult (<40 years) (5,000)
Case Race
Not Reported (5,000)
Case Ethnicity
Not Reported (5,000)
Case Disease Diagnosis
Neuroblastoma (5,000)
Case Tumor Site
Not Reported (5,000)
Number of Samples
6,313
Sample Assay Method
SNP Array (6,313)
Additional Data Elements
DBGAP STUDY IDENTIFIER
Grant Information
R01CA124709
The Genetic Basis of Neuroblastoma Tumorigenesis
Published In
https://doi.org/10.1002/ijc.31822;https://doi.org/10.1111/jcmm.13226
Charts
Not Reported (5,000)
5,000Not Reported