Pediatric Preclinical Testing Consortium
PPTC
Data Resource:  PPTC
Point of Contact:  
John M. Maris,  
Project

About This Dataset
Core Data Elements
Number of Cases
267
Case Sex
Female (90); Male (169); Not Reported (8)
Case Age At Diagnosis
0 to 4 years (86); 5 to 9 years (46); 10 to 14 years (50); 15 to 19 years (31); 20 to 24 years (5); 25 to 29 years (1); Pediatric and Young Adult (<40 years) (48)
Case Race
Asian (1); Black or African American (8); More Than One Race (1); White (7); Not Reported (17); Unknown (233)
Case Ethnicity
Hispanic or Latino (17); Not Hispanic or Latino (17); Unknown (233)
Case Disease Diagnosis
Alveolar Rhabdomyosarcoma (5); Alveolar Soft Part Sarcoma (2); Astrocytoma, NOS (3); Atypical Teratoid/Rhabdoid Tumor (8); B Lymphoblastic Leukemia/Lymphoma with T(9;22)(Q34;Q11.2); BCR-ABL1 (3); B Lymphoblastic Leukemia/Lymphoma with T(V;11Q23); Mll Rearranged (10); B Lymphoblastic Leukemia/Lymphoma, BCR-ABL1-Like (17); B Lymphoblastic Leukemia/Lymphoma, NOS (30); Carcinoma, NOS (1); Clear Cell Sarcoma, NOS (1); CNS Embryonal Tumor, NOS (4); Embryonal Rhabdomyosarcoma, NOS (6); Embryonal Tumor with Multilayered Rosettes with C19MC Alteration (3); Ependymoma, NOS (6); Ewing Sarcoma (10); Germinoma (1); Glioblastoma, NOS (6); Glioma, Malignant (2); Hepatoblastoma, NOS (1); Medulloblastoma, NOS (20); Nephroblastoma, NOS (13); Neuroblastoma, NOS (53); Osteosarcoma, NOS (33); Precursor T-Cell Lymphoblastic Leukemia (21); Rhabdoid Tumor, NOS (4); Small Cell Carcinoma, NOS (1); T Lymphoblastic Leukemia/Lymphoma (1); Unknown (2)
Case Tumor Site
Abdomen (7); Adrenal Gland (6); Blood (19); Bone (1); Bone Marrow (87); Bone of Limb (23); Bones of Skull and Face and Associated Joints (1); Brain (5); Brain Stem (3); Breast (1); Buttock (2); Cerebellum (30); Cerebrum (13); Frontal Lobe (1); Head, Face or Neck (1); Kidney (14); Liver (3); Lung (12); Lymph Node (1); Lymph Nodes of Head, Face and Neck (2); Occipital Lobe (1); Orbit (1); Parietal Lobe (1); Pelvis (1); Perineum (1); Pleura (1); Posterior Mediastinum (1); Retina (1); Retroperitoneum (5); Testis (1); Thigh (1); Tibia (5); Transverse Colon (1); Ventricle (2); Unknown (12)
Number of Samples
602
Sample Assay Method
RNA Sequencing (289); Whole Exome Sequencing (240)
Sample Is Normal
No (598); Yes (4)
Sample Is Xenograft
Yes (262); No (340)
Additional Data Elements
DBGAP STUDY IDENTIFIER
DATA REPOSITORY
Grant Information
U01CA199000
Pediatric Preclinical Testing Consortium - Leukemia
U01CA199221
Osteosarcoma: Patient Derived Xenograft Preclinical Testing
U01CA199287
Pediatric Preclinical Testing Consortium
U01CA199288
In Vivo Drug Testing Of Pediatric CNS Tumors Using Patient Derived Orthotopic Xenograft Models
U01CA199297
Pediatric Preclinical Testing Consortium: Research Programs non-CNS
Published In
https://doi.org/10.1016/j.celrep.2019.09.071;https://doi.org/10.1002/pbc.29304;https://doi.org/10.1158/1535-7163.MCT-20-0406
Charts
Male (169); Female (90); Not Reported (8)
169Male