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Center for Pediatric Tumor Cell Atlas - Children's Hospital of Philadelphia
HTAN
Data Resource:  HTAN
Point of Contact:  
Kristina A. Cole., M.D., Ph.D.,  
Collection

About This Dataset
The goal of the Center for Pediatric Tumor Cell Atlas (CPTCA) is to characterize molecular interactions at critical transition points in 3 deadly pediatric cancers: pediatric high grade glioma (pHGG), high risk neuroblastoma (HR NB) and very high-risk B-cell ALL (VHR ALL). Understanding how a tumor is molecularly changed at different transition points, such as in response to therapy and at the point of recurrence, could lead to advancements in care. In addition, the CPTCA's historical commitment to both resource and data sharing guarantee that the entire research and patient community will benefit. The Children's Brain Tumor Network contributed to this project by providing samples, genomic data and imaging data of rare pediatric brain cancer specimens necessary to carry out this line of questioning.
Core Data Elements
Number of Cases
30
Case Sex
Female (16); Male (9); Not Reported (5)
Case Age At Diagnosis
15 to 19 years (25); Pediatric and Young Adult (<40 years) (5)
Case Race
Not Reported (30)
Case Ethnicity
Not Reported (30)
Case Disease Diagnosis
Acute Leukemia, NOS (1); Acute Myeloid Leukemia, NOS (2); Precursor Cell Lymphoblastic Leukemia, NOS (22); Not Reported (5)
Case Tumor Site
Blood (22); Bone Marrow (8)
Case Treatment Administered
Chemotherapy (25); No Treatment (5)
Number of Samples
34
Sample Assay Method
ATAC (32); RNA Sequencing (34)
Sample Composition Type
Blood (24); Bone Marrow (10)
Additional Data Elements
DBGAP STUDY IDENTIFIER
DATA REPOSITORY
Grant Information
U2CCA233285
Center for pediatric tumor cell atlas
PROGRAM ID
RFA-CA-17-034
Published In
https://doi.org/10.1016/j.cell.2020.03.053
Charts
Female (16); Male (9); Not Reported (5)
16Female