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Radiation-related Genomic Profile of Papillary Thyroid Cancer after the Chernobyl Accident
GDC
Data Resource:  GDC
Point of Contact:  
Zhining Wang,  
Project

About This Dataset
The April 26, 1986 accident at the Chernobyl nuclear power plant in northern Ukraine resulted in the release of radioactive contaminants, which were deposited in the surrounding areas in Ukraine, Belarus, and Russia. The main radiation-related health effect resulting from these exposures is the increased occurrence of thyroid cancer among individuals who were children at the time of the accident or born shortly thereafter. The purpose of this study was to conduct a comprehensive genomic landscape analysis of papillary thyroid tumors arising in individuals who were exposed as children to radioactive iodine (I-131) from the Chernobyl nuclear power plant accident.
Core Data Elements
Number of Cases
12
Case Sex
Female (7); Male (5)
Case Age At Diagnosis
15 to 19 years (1); 20 to 24 years (2); 25 to 29 years (5); 30 to 34 years (3); 35 to 39 years (1)
Case Race
Not Reported (12)
Case Ethnicity
Not Reported (12)
Case Disease Diagnosis
Papillary adenocarcinoma, NOS (12)
Case Tumor Site
Thyroid gland (12)
Number of Samples
55
Sample Is Normal
Yes (22); No (24)
Additional Data Elements
DBGAP STUDY IDENTIFIER
DATA REPOSITORY
Grant Information
P01CA247773
Polymerase theta, genome instability, and cancer
R01CA097096
DNA Polymerases in Nonhomologous End Joining
U24CA082102
The Chernobyl Tissue Bank - Coordinating Center
ZIACP010132
Studies of Populations Exposed to Environmental Sources of Radiation
Published In
https://doi.org/10.1126/science.abg2538
SAMPLE TYPE
Blood Derived Normal (3);  
Primary Tumor (27);  
Solid Tissue Normal (25);  
Charts
Female (7); Male (5)
7Female