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Childhood Cancer Data Initiative (CCDI): Single-Cell Atlas of NF1 Nerve Sheath Tumors
CCDI
Data Resource:  CCDI
Point of Contact:  
Jack F. Shern, MD,  
Project

About This Dataset
The worst outcome of NF1 is the development of the aggressive and highly metastatic malignant peripheral nerve sheath tumors (MPNST), which transform from benign plexiform neurofibroma (PN) and lack effective treatment. In this study, we performed single-cell RNA sequencing of 63 clinically annotated NF1-associated peripheral nerve sheath tumors, including 24 PN, 34 premalignant atypical neurofibromas, and 5 MPNSTs. These results improve the ability of identifying high-risk neurofibromas and provide a unique opportunity for early detection of MPNST.
Core Data Elements
Number of Cases
29
Case Sex
Female (16); Male (13)
Case Age At Diagnosis
Pediatric and Young Adult (<40 years) (29)
Case Race
Not Reported (29)
Case Ethnicity
Not Reported (29)
Case Disease Diagnosis
Neurofibromatosis, NOS (29)
Case Tumor Site
Peripheral Nerves And Autonomic Nervous System (29)
Number of Samples
55
Sample Assay Method
Single-Cell RNA Sequencing (55)
Additional Data Elements
DBGAP STUDY IDENTIFIER
Grant Information
ZIDBC012137
Childhood Cancer Data Initiative
Published In
https://doi.org/10.1016/j.stem.2021.04.029;https://doi.org/10.1016/j.celrep.2022.111363;https://doi.org/10.1172/jci.insight.154513;https://doi.org/10.1016/j.xpro.2023.102297
Charts
Female (16); Male (13)
16Female