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Childhood Cancer Data Initiative (CCDI): CCDI Pediatric In Vivo Testing Program - Leukemia
CCDI
Data Resource:  CCDI
Point of Contact:  
Richard Lock, PhD,  
Project

About This Dataset
The goal of this study is to molecularly characterize a large panel of pediatric acute lymphoblastic leukemia (ALL) patient-derived xenografts (PDXs) previously established in immune-deficient mice. These PDXs are utilized as part of the NCI-funded Pediatric Preclinical In vivo Testing (PIVOT) program to identify novel agents and combinations. Biospecimen data include next-generation sequencing (RNAseq, whole exome sequencing, DNA copy number variation), whole-genome analysis of cytogenetic abnormalities, and DNA fingerprint for quality control.
Core Data Elements
Number of Cases
40
Case Sex
Female (17); Male (22); Not Reported (1)
Case Age At Diagnosis
0 to 4 years (20); 5 to 9 years (10); 10 to 14 years (7); 15 to 19 years (2); Pediatric and Young Adult (<40 years) (1)
Case Race
Unknown (40)
Case Ethnicity
Unknown (40)
Case Disease Diagnosis
B Lymphoblastic Leukemia/Lymphoma, NOS (31); T Lymphoblastic Leukemia/Lymphoma (9)
Case Tumor Site
Bone Marrow (40)
Number of Samples
252
Sample Assay Method
Amplicon (40); RNA Sequencing (24); Whole Exome Sequencing (40)
Sample Is Normal
No (252)
Additional Data Elements
DBGAP STUDY IDENTIFIER
Grant Information
APP1157871
National Health and Medical Research Council of Australia
U01CA199000
NCI Pediatric In Vivo Testing Program - Leukemia
Charts
Male (22); Female (17); Not Reported (1)
22Male