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Childhood Cancer Data Initiative (CCDI): Pediatric In Vivo Testing Program - Neuroblastoma
CCDI
Data Resource:  CCDI
Point of Contact:  
John M. Maris, MD,  
Project

About This Dataset
The goal of NCI's Pediatric In Vivo Testing Consortium (PIVOT) is to advance the development of effective treatments for pediatric cancers through preclinical in vivo testing of novel therapeutic agents. To design impactful experiments that can be rapidly translated to the clinic, PIVOT investigators require comprehensive genomic characterization of the patient-derived xenograft (PDX) models used across the consortium. This robust experimental design enhances collaboration with industry partners by providing proof-of-concept data for drugs in development. As part of this effort, neuroblastoma PDX models are being molecularly characterized to identify promising therapeutic candidates. The molecular profiling includes whole exome sequencing (WES), RNA-seq, MethylEPIC array, CytoSNP array, and DNA fingerprinting for quality control. Additionally, demographic and clinical data (e.g., diagnosis, disease site, disease status) are shared. These characterized PDX models, matched with patient tumors, guide model selection for preclinical drug testing.
Core Data Elements
Number of Cases
36
Case Sex
Female (16); Male (20)
Case Age At Diagnosis
0 to 4 years (13); 5 to 9 years (14); 10 to 14 years (3); Pediatric and Young Adult (<40 years) (6)
Case Race
Asian (2); Black or African American (6); White (20); Not Reported (7); Unknown (1)
Case Ethnicity
Hispanic or Latino (2); Not Hispanic or Latino (26); Not Reported (7); Unknown (1)
Case Disease Diagnosis
Neuroblastoma (36)
Case Tumor Site
Blood (5); Bone (4); Bone Marrow (4); Connective, Subcutaneous and Other Soft Tissues, NOS (1); Lung (2); Lymph Node (3); Retroperitoneum (1); Not Reported (16)
Number of Samples
250
Sample Assay Method
Amplicon (36); Methylation Array (35); RNA Sequencing (36); Whole Exome Sequencing (35)
Sample Is Normal
No (250)
Additional Data Elements
DBGAP STUDY IDENTIFIER
Grant Information
U01CA263957
NCI Pediatric In Vivo Testing Program: Neuroblastoma
Published In
https://doi.org/10.1016/j.celrep.2019.09.071
Charts
Male (20); Female (16)
20Male